The Vascular or Veinous system consists of an intricate network of Vein and Capilliaries of various sizes that conduct the blood back from the periphery of the body to the Lungs and Heart where it is reoxygenated and pumped back through the body. The larger Veins are three layered like the Arteries and even sometimes include reverse siphoning valves to prevent backflow; they are damaged in much the same way that Arteries are damaged by Atherosclerosis. The backflow valves function in the low pressure Veinous system in conjunction with the skeletal muscles to cause the blood to flow back to the Heart, sometimes against gravity. The way that it works is to sort of milk the veins to force low pressure blood to flow uphill when the muscle flexes and to prevent backflow downhill with the valves when the muscle relaxes.
The smaller Veins and Capilliaries are designed quite differently. They are composed of but a single layer. The most common Vascular disease occurs when the permeability between the tight junctions of the Venous Endothelilial cells of this single layered blood conduit increases and the Veins "leak". This is referred to as Angiopathy; it occurs frequently whenever the Blood Sugar Control System fails to function properly. Serious leaking produces hemorrhage; this is causal in one of the two types of Stroke that affects the Hyperinsulinemic.
High Glucose concentrations in Veinous blood have been directly related in a causal way to this increased permeability of the Vascular system. Both post prandial (after eating) spikes in the Glucose level, as well as chronic elevated fasting Glucose levels are implicated in the increased permeability of Vascular Disease.
Certain organs of the body, having a high density of Capilliaries, Microvascular conduits and a high density of low pressure blood are particularly affected by the high concentration of Glucose that remains in the blood stream. Thus, blindness because of Retinopathy, as well as Kidney Failure and Liver damage are among the early consequences of Vascular disease. Later consequences include Gangrene.
A high density of Glucose in the blood is caused directly by the loss of Insulin effectiveness. In this disease, our Pancreatic beta sites secrete adequate, competant Insulin. However, because of cellular changes within each of our 67 trillion or so cells the cells do not correctly respond to the insulin that they see. Glucose is not swept out of the blood stream into our cells and the Insulin is perceived to be ineffective. When the blood glucose level remains high because of this ineffectiveness of insulin, Type II diabetes is diagnosed. By the time Type II diabetes is diagnosed Vascular disease exists. When the blood Glucose level remains high because of insufficient Insulin, Type 1 diabetes is diagnosed and Vascular disease results. When the blood Glucose level remains high because our cells no longer correctly respond to Insulin, Type II diabetes is diagnosed and Vascular disease rsults. Approximately 95% of all of the diabetes in the country is Type 2 diabetes..
When insulin loses its effectiveness, our Pancreas responds by secreting more in an effort to lower blood Glucose levels. This is how Hyperinsulinemia develops. Glucose sensors in the portal vein cause the Pancreas to secrete Insulin whenever the blood Glucose is high. Thus Vascular disease has this intimate association with Hyperinsulinemia and with Type II diabetes..
To discover why Insulin loses its effectiveness and elevated blood Glucose levels develop to cause Vascular disease see our page on Type II diabetes. To see how to cure the disease see our page on Hyperinsulinemia.
For those who are interested in the source data from which these conclusions are drawn the starter list of references on the bottom of this page is provided. These are just a few of the many excellent studies that have been done to define vascular disease. Further information and more scientific cites and references are available in our Special Report on the causal role that Hyperinsulinemia plays in this disease.
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